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Edgars Liepinsh Selected Research

Carnitine (L-Carnitine)

1/2023Knockout of Tmlhe in mice is not associated with autism spectrum disorder phenotypes or motor dysfunction despite low carnitine levels.
11/2020Rats with congenital hydronephrosis show increased susceptibility to renal ischemia-reperfusion injury.
11/2018Letter to the Editor: "Serum Carnitine Metabolites and Incident Type 2 Diabetes Mellitus in Patients With Suspected Stable Angina Pectoris".
8/2017Decrease in Long-Chain Acylcarnitine Tissue Content Determines the Duration of and Correlates with the Cardioprotective Effect of Methyl-GBB.
9/2015Methyl-γ-butyrobetaine decreases levels of acylcarnitines and attenuates the development of atherosclerosis.
7/2014Selective inhibition of OCTN2 is more effective than inhibition of gamma-butyrobetaine dioxygenase to decrease the availability of l-carnitine and to reduce myocardial infarct size.
1/2014Mildronate, the inhibitor of L-carnitine transport, induces brain mitochondrial uncoupling and protects against anoxia-reoxygenation.
6/2013Activated peroxisomal fatty acid metabolism improves cardiac recovery in ischemia-reperfusion.
6/2012The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine.
5/2012High L-carnitine concentrations do not prevent late diabetic complications in type 1 and 2 diabetic patients.
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Edgars Liepinsh Research Topics

Disease

10Infarction (Infarctions)
12/2023 - 12/2006
9Ischemia
12/2023 - 08/2002
7Insulin Resistance
03/2022 - 11/2016
7Type 2 Diabetes Mellitus (MODY)
12/2020 - 08/2009
5Reperfusion Injury
12/2023 - 08/2009
5Myocardial Infarction
01/2021 - 08/2009
4Inflammation (Inflammations)
12/2021 - 12/2005
4Hyperglycemia
01/2021 - 05/2011
4Atherosclerosis
11/2016 - 01/2009
4Encephalitis (Encephalitis, Rasmussen)
04/2010 - 12/2005
3Hypoxia (Hypoxemia)
12/2023 - 01/2014
3Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
12/2023 - 09/2011
3Cardiovascular Diseases (Cardiovascular Disease)
02/2017 - 11/2014
3Diabetes Complications
05/2012 - 08/2009
2Neuroinflammatory Diseases
01/2024 - 01/2004
2Pyelonephritis
11/2021 - 03/2020
2Metabolic Syndrome (Dysmetabolic Syndrome X)
01/2021 - 01/2017
2Hyperlipidemias (Hyperlipidemia)
12/2020 - 05/2011
2Mitochondrial Diseases (Mitochondrial Disease)
12/2020 - 02/2017
2Heart Failure
12/2020 - 11/2016
2Glucose Intolerance
09/2017 - 05/2011
2Body Weight (Weight, Body)
01/2017 - 12/2007
2Obesity
01/2017 - 05/2011
2Weight Gain
01/2017 - 05/2011
2Cardiac Arrhythmias (Arrythmia)
11/2016 - 08/2009
2Brain Ischemia (Cerebral Ischemia)
11/2016 - 09/2011
2Atherosclerotic Plaque (Atheroma)
09/2015 - 01/2009
2Hypertension (High Blood Pressure)
01/2014 - 01/2011
2Necrosis
04/2010 - 08/2009
2Pain (Aches)
08/2009 - 03/2008
1Liver Failure
04/2024
1Sepsis (Septicemia)
04/2024
1Post-Acute COVID-19 Syndrome
01/2024
1Fatigue
01/2024
1Autism Spectrum Disorder
01/2023
1Ventricular Dysfunction
12/2021
1Pulmonary Hypertension
12/2021
1Hypertrophy
12/2021
1COVID-19
12/2021
1Left Ventricular Dysfunction
12/2021
1Infections
11/2021
1Urinary Tract Infections (Urinary Tract Infection)
11/2021
1Hydronephrosis
11/2020
1Acute Kidney Injury (Acute Renal Failure)
11/2020

Drug/Important Bio-Agent (IBA)

15Carnitine (L-Carnitine)FDA LinkGeneric
01/2023 - 12/2006
133-(2,2,2-trimethylhydrazine)propionateIBA
12/2021 - 08/2002
12Fatty Acids (Saturated Fatty Acids)IBA
04/2024 - 08/2009
10Glucose (Dextrose)FDA LinkGeneric
04/2024 - 08/2009
9acylcarnitineIBA
12/2023 - 09/2015
5trimethyloxamine (trimethylamine N-oxide)IBA
02/2023 - 11/2014
4methyl-gamma-butyrobetaineIBA
12/2023 - 09/2015
4Insulin (Novolin)FDA Link
06/2021 - 01/2014
3LipopolysaccharidesIBA
10/2020 - 12/2007
3Blood Glucose (Blood Sugar)IBA
01/2017 - 08/2009
3Nitric Oxide (Nitrogen Monoxide)FDA Link
04/2010 - 06/2006
3MelanocortinsIBA
06/2006 - 01/2004
2Pyruvic Acid (Pyruvate)IBA
01/2021 - 10/2020
2LipidsIBA
12/2020 - 01/2019
2Metformin (Glucophage)FDA LinkGeneric
01/2020 - 05/2011
2PalmitoylcarnitineIBA
09/2017 - 01/2016
24-amino-3-phenylbutyric acid (phenibut)IBA
11/2016 - 03/2008
2Apolipoproteins E (ApoE)IBA
09/2015 - 01/2009
2gamma-butyrobetaine (butyrobetaine)IBA
09/2015 - 12/2006
22- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA
06/2013 - 06/2012
2EnzymesIBA
05/2013 - 03/2011
2SaltsIBA
01/2011 - 08/2009
21- (3,4- dimethoxy- 2- - chlorobenzylideneamino)guanidineIBA
04/2010 - 08/2004
2NF-kappa B (NF-kB)IBA
04/2010 - 12/2005
2Melanocortin Receptors (Melanocortin Receptor)IBA
12/2007 - 12/2005
2Peptides (Polypeptides)IBA
12/2005 - 01/2004
1Blood Proteins (Serum Proteins)IBA
04/2024
1Acetylcarnitine (Alcar)IBA
01/2024
1Reactive Oxygen Species (Oxygen Radicals)IBA
12/2023
1triphenyltetrazoliumIBA
12/2023
1trimethyl-lysine hydroxylaseIBA
01/2023
1Insulin-Like Growth Factor I (IGF-1)IBA
03/2022
1C-PeptideIBA
03/2022
1Ketone BodiesIBA
03/2022
1AminesIBA
11/2021
1Gentamicins (Gentamicin)FDA LinkGeneric
11/2021
1Anti-Bacterial Agents (Antibiotics)IBA
11/2021
1AminoglycosidesIBA
11/2021
1Amikacin (A.M.K)FDA LinkGeneric
11/2021
1apramycinIBA
11/2021
1NADPH Oxidase 2IBA
01/2021
1itaconic acidIBA
01/2021
1Succinic Acid (Succinate)IBA
01/2021
1HexokinaseIBA
01/2021
1Succinate Dehydrogenase (Fumarate Reductase)IBA
01/2021
1Sodium-Glucose Transporter 2 InhibitorsIBA
12/2020
1empagliflozinIBA
12/2020
1Sodium-Glucose Transport ProteinsIBA
12/2020
1Furosemide (Lasix)FDA LinkGeneric
11/2020
1Fatty Acid Synthases (Fatty Acid Synthase)IBA
10/2020
1AMP-Activated Protein KinasesIBA
10/2020
14- hydroxy- 3- (4- (2- hydroxyphenyl)phenyl)- 6- oxo- 7H- thieno(2,3- b)pyridine- 5- carbonitrileIBA
10/2020
1Polymyxins (Polymyxin)IBA
03/2020
1Polymyxin B (Aerosporin)FDA LinkGeneric
03/2020
1NAB 739 peptideIBA
03/2020

Therapy/Procedure

1Drug Therapy (Chemotherapy)
11/2020